PHF11

Across TCGA pan-cancer cohorts, PHF11 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PHF11 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PHF11 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PHF11 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUAD, OV, and CCRCC are the cancer types where PHF11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.856	0.474	<.001	20	view →
OV	DFS	Median	All	0.697	1.000	.022	4	view →
CCRCC	OS	Median	II,III,IV	0.867	1.000	.048	1	view →
PDAC	DFS	Quartile	All	0.603	0.839	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PHF11–LUAD (DFS)

Open the LUAD breakdown →