PHF11

Across TCGA patient cohorts, PHF11 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF11-associated genes across cancer lineages are VHL, Chk2_pT68, and 14-3-3_beta. Each is linked with PHF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF11-to-partner and partner-to-PHF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by PHF11-low versus PHF11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF11→partner) and Y-score (partner→PHF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.722	-1.584	.003	.034	3	2
UCEC	Chk2_pT68 →	-0.139	-3.160	.041	.019	3	2
UCEC	14-3-3_beta →	-0.092	-1.847	.012	.049	3	1
UCEC	EGFR_pY1068 →	-0.200	-2.584	.030	.010	3	1
UCEC	INPP4B →	-0.245	-2.584	.039	.010	3	1
UCEC	JNK2 →	+0.188	+1.847	.010	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

VHL by PHF11 expression — UCEC

Explore this box plot interactively →