PHF10

Across TCGA pan-cancer cohorts, PHF10 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PHF10 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PHF10 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PHF10 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where PHF10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.673	0.971	<.001	62	view →
CCRCC	DFS	Median	IV	0.781	0.220	.017	11	view →
LUAD	OS	Median	All	1.000	0.767	.004	8	view →
OV	DFS	Median	All	0.829	1.000	.010	4	view →
UCEC	OS	Tertile	All	0.914	1.000	.025	4	view →
GBM	DFS	Median	All	0.471	0.286	.015	2	view →
LSCC	DFS	Median	All	0.972	0.906	.008	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PHF10–HNSC (OS)

Open the HNSC breakdown →