PHF10

Across TCGA patient cohorts, PHF10 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF10-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with PHF10 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF10-to-partner and partner-to-PHF10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PHF10-low versus PHF10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF10→partner) and Y-score (partner→PHF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.401	-2.000	.012	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.595	+2.434	.004	.001	3	2
UCEC	14-3-3_beta →	-0.082	-3.432	.021	.005	3	1
UCEC	eIF4E →	+0.152	+3.183	.041	.009	3	1
UCEC	INPP4B →	-0.289	-2.906	.011	.001	3	1
UCEC	JNK2 →	+0.191	+2.392	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

ATM by PHF10 expression — UCEC

Explore this box plot interactively →