PHF10

Across TCGA cell cohorts, PHF10 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHF10-associated genes across cancer lineages are PLA2G3, INPP5K, and CCDC54. Each is linked with PHF10 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF10-to-partner and partner-to-PHF10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLA2G3 grouped by PHF10-low versus PHF10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF10→partner) and Y-score (partner→PHF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLA2G3 →	+1.242	+3.215	<.001	.009	3	1
LARGE_INTESTINE	INPP5K →	+0.656	+3.064	.005	.009	3	1
LARGE_INTESTINE	CCDC54 →	+0.094	+3.000	.004	.003	3	1
LARGE_INTESTINE	MCHR2 →	+0.014	+2.777	.001	.004	3	1
LARGE_INTESTINE	SAXO1 →	+0.037	+3.567	.002	.002	3	1
LARGE_INTESTINE	TNK1 →	+0.816	+3.064	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PLA2G3 by PHF10 expression — LARGE_INTESTINE

Explore this box plot interactively →