PHF1

Across TCGA pan-cancer cohorts, PHF1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PHF1 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PHF1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PHF1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where PHF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.861	0.534	.003	43	view →
PDAC	OS	Median	III,IV	0.929	0.550	<.001	31	view →
LUAD	DFS	Median	All	0.978	0.636	.005	17	view →
UCEC	OS	Median	II,III,IV	0.609	1.000	.008	12	view →
GBM	DFS	Quartile	All	0.890	0.617	.011	2	view →
LSCC	DFS	Tertile	II,III,IV	0.472	0.760	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PHF1–CCRCC (DFS)

Open the CCRCC breakdown →