PHF1

Across TCGA patient cohorts, PHF1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,850 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PHF1-associated genes across cancer lineages are ZNF540, CBX7, and SIGLEC6. Each is linked with PHF1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PHF1-to-partner and partner-to-PHF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHF1 versus ZNF540 in BRCA, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF1→partner) and Y-score (partner→PHF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF540 →	+0.713	+0.198	<.001	<.001	3	7
BRCA	CBX7 →	+0.797	+0.272	<.001	<.001	3	6
UCEC	SIGLEC6 →	+0.644	+0.351	<.001	<.001	3	6
HNSC	GLCCI1 →	+0.982	+0.301	<.001	<.001	3	6
UCEC	SPARCL1 →	+1.096	+0.228	<.001	<.001	3	6
BRCA	GNG7 →	+0.658	+0.205	.002	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,850 associations by consensus.

PHF1 vs ZNF540 — BRCA

Explore this scatter interactively →