PHF1

Across TCGA patient cohorts, PHF1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF1-associated genes across cancer lineages are Caspase-8, C-Raf, and EGFR_pY1068. Each is linked with PHF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF1-to-partner and partner-to-PHF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by PHF1-low versus PHF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF1→partner) and Y-score (partner→PHF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.245	-3.700	.015	.001	3	2
UCEC	C-Raf →	+0.179	+1.906	.001	.016	3	2
UCEC	EGFR_pY1068 →	-0.288	-2.115	.004	.017	3	1
UCEC	A-Raf_pS299 →	-0.158	-2.000	.001	.030	3	1
UCEC	ERK2 →	+0.210	+2.700	.006	.006	3	1
UCEC	FoxM1 →	+0.231	+2.415	.026	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Caspase-8 by PHF1 expression — UCEC

Explore this box plot interactively →