PHF1

Across TCGA cell cohorts, PHF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,923 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHF1-associated GO terms across cancer lineages are Proteinogenic amino acid catabolic process, Alpha-amino acid catabolic process, and COPI-coated vesicle budding. Each is linked with PHF1 in more than 11 cancer types. Because this analysis shows association rather than direction, both PHF1-to-partner and partner-to-PHF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Proteinogenic amino acid catabolic process grouped by PHF1-low versus PHF1-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF1→partner) and Y-score (partner→PHF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Proteinogenic amino acid catabolic process →	-0.086	-0.753	<.001	<.001	3	11
LUNG_NSCLC_LUAD	Alpha-amino acid catabolic process →	-0.079	-0.745	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	COPI-coated vesicle budding →	+0.145	+0.855	<.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Golgi transport vesicle coating →	+0.145	+0.855	<.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	COPI coating of Golgi vesicle →	+0.145	+0.855	<.001	.001	3	11
BLOOD_Myeloma	Macroautophagy →	+0.070	+0.811	<.001	<.001	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,923 associations by consensus.

Proteinogenic amino acid catabolic process by PHF1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →