PHF1

Across TCGA cell cohorts, PHF1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHF1-associated genes across cancer lineages are USP14, MCHR2, and OXA1L. Each is linked with PHF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF1-to-partner and partner-to-PHF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP14 grouped by PHF1-low versus PHF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF1→partner) and Y-score (partner→PHF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	USP14 →	+0.764	+3.067	.001	.009	3	1
LARGE_INTESTINE	MCHR2 →	+0.012	+2.777	.009	.004	3	1
LARGE_INTESTINE	OXA1L →	+0.526	+3.067	.001	.009	3	1
LARGE_INTESTINE	CHSY3 →	+0.345	+3.302	.006	.008	3	1
LARGE_INTESTINE	MYMX →	+0.279	+2.648	<.001	.008	3	1
LARGE_INTESTINE	SIKE1 →	+0.627	+3.064	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

USP14 by PHF1 expression — LARGE_INTESTINE

Explore this box plot interactively →