PHEX

Across TCGA pan-cancer cohorts, PHEX Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PHEX data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher PHEX Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PHEX expression acts as an unfavorable survival marker, although some lineages such as UCEC and SCLC show a favorable association.

THYM, UCEC, and BRCA are the cancer types where PHEX Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	All	0.673	0.983	<.001	36	view →
UCEC	DFS	Median	All	0.954	0.606	.003	22	view →
BRCA	DFS	Median	III,IV	0.093	0.880	<.001	12	view →
LUSC	OS	Median	II,III,IV	0.179	0.687	.004	12	view →
SCLC	DFS	Median	All	1.000	0.264	.019	7	view →
SARC	OS	Median	All	0.183	0.827	<.001	6	view →
SKCM	DFS	Median	III,IV	0.087	0.647	.013	3	view →
LUAD	DFS	Median	All	1.000	0.664	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PHEX–THYM (OS)

Open the THYM breakdown →