PHETA2

Across TCGA patient cohorts, PHETA2 mutation is significantly associated with the RNA expression of many other genes, with 107 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHETA2-associated genes across cancer lineages are RNU6-947P, NOL12, and ALPI. Each is linked with PHETA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHETA2-to-partner and partner-to-PHETA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-947P grouped by PHETA2-low versus PHETA2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHETA2→partner) and Y-score (partner→PHETA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-947P →	+0.258	+7.816	<.001	.008	3	2
UCEC	NOL12 →	+0.395	+3.354	.009	.005	3	1
UCEC	ALPI →	+0.558	+3.547	<.001	.003	3	1
UCEC	SMIM4 →	+0.739	+3.364	<.001	.005	3	1
UCEC	PPIP5K1 →	+0.566	+3.375	.001	.004	3	1
UCEC	C2CD2L →	+0.653	+3.364	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 107 associations by consensus.

RNU6-947P by PHETA2 expression — SKCM

Explore this box plot interactively →