PHC3

Across TCGA pan-cancer cohorts, PHC3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PHC3 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PHC3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PHC3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LUAD, CCRCC, and GBM are the cancer types where PHC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.922	0.643	.001	29	view →
CCRCC	OS	Median	III,IV	0.890	0.522	.002	18	view →
GBM	OS	Tertile	All	0.644	0.388	.003	17	view →
PDAC	DFS	Median	All	0.828	0.700	.016	7	view →
HNSC	DFS	Median	IV	0.573	0.822	.013	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PHC3–LUAD (OS)

Open the LUAD breakdown →