PHC3

Across TCGA patient cohorts, PHC3 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHC3-associated genes across cancer lineages are Rad50, ATM, and GATA3. Each is linked with PHC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHC3-to-partner and partner-to-PHC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by PHC3-low versus PHC3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHC3→partner) and Y-score (partner→PHC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Rad50 →	-0.395	-2.987	.012	.035	2	3
SKCM	ATM →	-0.675	-3.169	.001	.019	3	2
UCEC	GATA3 →	-0.148	-1.979	.013	.009	3	2
UCEC	p90 RSK →	+0.173	+1.536	.004	.005	3	2
UCEC	Annexin-1 →	+0.383	+1.926	.022	.008	3	2
SKCM	A-Raf_pS299 →	+0.252	+2.820	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Rad50 by PHC3 expression — SKCM

Explore this box plot interactively →