PHC3

Across TCGA cell cohorts, PHC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,560 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHC3-associated GO terms across cancer lineages are Negative regulation of DNA-templated transcription initiation, Negative regulation of transcription initiation by RNA polymerase II, and CAMP/PKA signal transduction. Each is linked with PHC3 in more than 16 cancer types. Because this analysis shows association rather than direction, both PHC3-to-partner and partner-to-PHC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of DNA-templated transcription initiation grouped by PHC3-low versus PHC3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHC3→partner) and Y-score (partner→PHC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of DNA-templated transcription initiation →	+0.138	+1.031	.001	.001	3	17
STOMACH	Negative regulation of transcription initiation by RNA polymerase II →	+0.138	+1.031	.001	.001	3	17
UPPER_AERODIGESTIVE_TRACT	CAMP/PKA signal transduction →	+0.201	+1.233	<.001	.002	3	16
CNS	Regulation of protein localization to nucleus →	+0.080	+0.961	<.001	<.001	3	16
LARGE_INTESTINE	Response to dehydroepiandrosterone →	+0.244	+1.333	.004	<.001	3	16
STOMACH	Retrograde transport, endosome to Golgi →	+0.085	+1.023	.004	.007	2	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,560 associations by consensus.

Negative regulation of DNA-templated transcription initiation by PHC3 expression — STOMACH

Explore this box plot interactively →