PHC3

Across TCGA cell cohorts, PHC3 mutation is significantly associated with the RNA expression of many other genes, with 186 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHC3-associated genes across cancer lineages are PCDH11Y, SIGLEC6, and IL18RAP. Each is linked with PHC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHC3-to-partner and partner-to-PHC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCDH11Y grouped by PHC3-low versus PHC3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHC3→partner) and Y-score (partner→PHC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PCDH11Y →	+0.016	+5.087	<.001	.004	3	2
BONE	SIGLEC6 →	+0.037	+3.672	<.001	.004	3	1
BONE	IL18RAP →	+0.042	+3.906	<.001	.004	3	1
BONE	SCGB1D2 →	+0.134	+3.906	.008	.004	3	1
BONE	GSX2 →	+0.204	+3.906	<.001	.004	3	1
BONE	MS4A12 →	+0.078	+3.672	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 186 associations by consensus.

PCDH11Y by PHC3 expression — URINARY_TRACT

Explore this box plot interactively →