PHC2

Across TCGA patient cohorts, PHC2 protein abundance is significantly associated with the RNA expression of many other genes, with 12,880 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible PHC2-associated genes across cancer lineages are MEX3A, RBBP4, and TMEM39B. Each is linked with PHC2 in more than 5 cancer types. Because this analysis shows association rather than direction, both PHC2-to-partner and partner-to-PHC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHC2 versus MEX3A in LSCC, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHC2→partner) and Y-score (partner→PHC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MEX3A →	+1.170	+0.334	.001	.004	3	6
LSCC	RBBP4 →	+0.602	+0.435	<.001	<.001	3	6
BRCA	TMEM39B →	+0.581	+0.290	<.001	<.001	3	5
GBM	MARCKSL1 →	+1.223	+0.461	<.001	<.001	3	5
GBM	TRAF3IP2-AS1 →	+0.578	+0.283	<.001	.002	3	4
OV	TRO →	+1.047	+0.279	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,880 associations by consensus.

PHC2 vs MEX3A — LSCC

Explore this scatter interactively →