PHC2

Across TCGA patient cohorts, PHC2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHC2-associated genes across cancer lineages are MEK1, ATM, and eEF2. Each is linked with PHC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHC2-to-partner and partner-to-PHC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PHC2-low versus PHC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHC2→partner) and Y-score (partner→PHC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.392	+2.999	<.001	<.001	3	2
UCEC	ATM →	-0.424	-2.794	.002	.002	3	2
UCEC	eEF2 →	+0.292	+1.263	.007	.019	3	1
UCEC	eIF4E →	+0.156	+2.087	.015	.005	3	1
UCEC	ERK2 →	+0.180	+1.999	.002	.008	3	1
UCEC	IGFBP2 →	-0.628	-1.584	.001	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

MEK1 by PHC2 expression — UCEC

Explore this box plot interactively →