PHC2

Across TCGA cell cohorts, PHC2 mutation is significantly associated with the RNA expression of many other genes, with 125 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHC2-associated genes across cancer lineages are UFSP2, MRPL18, and PCCB. Each is linked with PHC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHC2-to-partner and partner-to-PHC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UFSP2 grouped by PHC2-low versus PHC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHC2→partner) and Y-score (partner→PHC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UFSP2 →	+0.494	+3.212	.009	.006	3	1
LARGE_INTESTINE	MRPL18 →	+0.443	+3.212	.003	.006	3	1
LARGE_INTESTINE	PCCB →	+0.590	+3.299	.002	.004	3	1
LARGE_INTESTINE	TCP1 →	+0.530	+3.212	.008	.006	3	1
LARGE_INTESTINE	SCLT1 →	+0.559	+3.212	.003	.006	3	1
LARGE_INTESTINE	S100G →	+0.827	+2.688	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 125 associations by consensus.

UFSP2 by PHC2 expression — LARGE_INTESTINE

Explore this box plot interactively →