PHC1P1

Across TCGA patient cohorts, PHC1P1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PHC1P1-associated genes across cancer lineages are LIMS3, FTHL17, and GK2. Each is linked with PHC1P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHC1P1-to-partner and partner-to-PHC1P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIMS3 grouped by PHC1P1-low versus PHC1P1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHC1P1→partner) and Y-score (partner→PHC1P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LIMS3 →	+0.033	+4.841	<.001	.006	3	1
BRCA	FTHL17 →	+1.733	+4.500	<.001	.005	3	1
BRCA	GK2 →	+0.038	+6.697	<.001	<.001	3	1
BRCA	RNU4-90P →	+0.220	+5.016	.003	.005	3	1
BRCA	RNA5SP36 →	+0.229	+4.971	<.001	.005	3	1
BRCA	RN7SKP29 →	+0.341	+4.540	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

LIMS3 by PHC1P1 expression — BRCA

Explore this box plot interactively →