PHC1

Across TCGA pan-cancer cohorts, PHC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PHC1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PHC1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PHC1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

UCEC, CCRCC, and HNSC are the cancer types where PHC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.836	1.000	.013	10	view →
CCRCC	OS	Median	All	1.000	0.600	.025	7	view →
HNSC	DFS	Tertile	IV	0.277	0.809	.038	4	view →
PDAC	OS	Tertile	III,IV	0.922	0.272	.036	4	view →
LUAD	DFS	Median	III,IV	0.345	0.696	.020	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PHC1–UCEC (OS)

Open the UCEC breakdown →