PHC1

Across TCGA patient cohorts, PHC1 mutation is significantly associated with the RNA expression of many other genes, with 3,041 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHC1-associated genes across cancer lineages are ARHGAP11A, LACTB, and SDHB. Each is linked with PHC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHC1-to-partner and partner-to-PHC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARHGAP11A grouped by PHC1-low versus PHC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHC1→partner) and Y-score (partner→PHC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARHGAP11A →	+0.521	+3.700	.005	.001	3	3
UCEC	LACTB →	+0.466	+3.201	<.001	<.001	3	3
UCEC	SDHB →	+0.413	+2.432	<.001	<.001	3	3
UCEC	SUPV3L1 →	+0.333	+1.788	.002	.001	3	3
UCEC	MELK →	+0.643	+3.818	.001	<.001	3	3
COAD	RAB27A →	+0.706	+3.331	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,041 associations by consensus.

ARHGAP11A by PHC1 expression — UCEC

Explore this box plot interactively →