PHC1

Across TCGA patient cohorts, PHC1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHC1-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and ERK2. Each is linked with PHC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHC1-to-partner and partner-to-PHC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PHC1-low versus PHC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHC1→partner) and Y-score (partner→PHC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.168	+3.335	.026	.005	3	2
UCEC	A-Raf_pS299 →	-0.134	-2.906	.001	.001	3	2
UCEC	ERK2 →	+0.196	+3.584	.004	.002	3	2
UCEC	MSH2 →	-0.264	-1.973	.001	.029	3	2
UCEC	Caspase-7-cleavedD198 →	+0.659	+2.341	.002	.003	3	2
UCEC	Chk2_pT68 →	-0.160	-2.690	.016	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

eIF4E by PHC1 expression — UCEC

Explore this box plot interactively →