PHC1

Across TCGA cell cohorts, PHC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,326 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHC1-associated GO terms across cancer lineages are Heterochromatin organization, Regulation of nucleotide-excision repair, and Heterochromatin formation. Each is linked with PHC1 in more than 16 cancer types. Because this analysis shows association rather than direction, both PHC1-to-partner and partner-to-PHC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heterochromatin organization grouped by PHC1-low versus PHC1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHC1→partner) and Y-score (partner→PHC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Heterochromatin organization →	+0.085	+0.913	<.001	.004	3	17
BONE	Regulation of nucleotide-excision repair →	+0.139	+1.505	<.001	<.001	3	16
OVARY	Heterochromatin formation →	+0.066	+1.055	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of transcription by RNA polymerase III →	+0.142	+0.876	<.001	.008	3	15
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.174	+1.798	.003	.009	3	15
BONE	Negative regulation of gene expression, epigenetic →	+0.085	+1.129	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,326 associations by consensus.

Heterochromatin organization by PHC1 expression — LUNG_SCLC

Explore this box plot interactively →