PHC1

Across TCGA cell cohorts, PHC1 mutation is significantly associated with the RNA expression of many other genes, with 210 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHC1-associated genes across cancer lineages are NUPR2, SEMG2, and DCD. Each is linked with PHC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHC1-to-partner and partner-to-PHC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUPR2 grouped by PHC1-low versus PHC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHC1→partner) and Y-score (partner→PHC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NUPR2 →	+0.159	+2.425	.004	.004	3	2
LUNG_SCLC	SEMG2 →	+0.031	+4.269	.002	.005	3	1
LUNG_SCLC	DCD →	+1.085	+4.643	<.001	.004	3	1
LUNG_SCLC	DPPA3 →	+0.039	+4.269	<.001	.005	3	1
LUNG_SCLC	GOLGA6L6 →	+0.025	+4.044	<.001	.009	3	1
BLOOD_Leukemia	GZMK →	+0.579	+4.037	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 210 associations by consensus.

NUPR2 by PHC1 expression — LARGE_INTESTINE

Explore this box plot interactively →