PHBP19

Across TCGA pan-cancer cohorts, PHBP19 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PHBP19’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where PHBP19 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PHBP19 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

LIHC, THCA, and HNSC are the cancer types where PHBP19 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHBP19 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	All	+0.067	.001	6	view →
THCA	Female	All	−0.219	<.001	5	view →
HNSC	All	All	+0.112	.002	5	view →
CHOL	All	II,III,IV	+1.070	<.001	4	view →
READ	All	All	+0.707	.005	4	view →
STAD	All	All	+0.585	.009	4	view →
COAD	All	All	+0.331	<.001	4	view →
KIRP	All	IV	+0.244	.005	2	view →
LUSC	Male	All	+0.190	.023	2	view →
PRAD	All	All	+0.130	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PHBP19–LIHC

Open the LIHC breakdown →