Across TCGA patient cohorts, PHB2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHB2-associated genes across cancer lineages are PRDX1, Ku80, and Src_pY527. Each is linked with PHB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHB2-to-partner and partner-to-PHB2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHB2→partner) and Y-score (partner→PHB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRDX1 →	+0.220	+3.000	.041	.036	3	2
UCEC	Ku80 →	+0.321	+2.183	.009	.035	3	1
UCEC	Src_pY527 →	-0.620	-3.321	.005	.010	3	1
UCEC	STAT3_pY705 →	-0.424	-3.159	.001	.019	3	1
UCEC	VHL →	-1.504	-3.321	<.001	.010	3	1
UCEC	4E-BP1_pT37_T46 →	-0.490	-3.321	.012	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

PHB2 survival (RNA) · tumor vs normal (RNA) · all PHB2 data types