Across TCGA cell cohorts, PHB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,528 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PHB2-associated GO terms across cancer lineages are rRNA metabolic process, Nucleolar large rRNA transcription by RNA polymerase I, and Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with PHB2 in more than 14 cancer types. Because this analysis shows association rather than direction, both PHB2-to-partner and partner-to-PHB2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHB2→partner) and Y-score (partner→PHB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	rRNA metabolic process →	+0.113	+0.558	<.001	<.001	3	15
BONE	Nucleolar large rRNA transcription by RNA polymerase I →	+0.118	+0.627	<.001	<.001	3	14
LIVER	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.139	+0.687	.005	.009	2	15
BONE	'de novo' UMP biosynthetic process →	+0.140	+0.786	.001	<.001	3	13
BLOOD_Myeloma	tRNA aminoacylation for mitochondrial protein translation →	+0.117	+1.071	<.001	.001	3	13
BONE	Mitochondrial large ribosomal subunit assembly →	+0.148	+0.721	<.001	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,528 associations by consensus.

Exploration

PHB2 survival (RNA) · tumor vs normal (RNA) · all PHB2 data types