PHB

Across TCGA patient cohorts, PHB protein abundance is significantly associated with the RNA expression of many other genes, with 14,699 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PHB-associated genes across cancer lineages are RIPOR2, EMG1, and PHB2. Each is linked with PHB in more than 7 cancer types. Because this analysis shows association rather than direction, both PHB-to-partner and partner-to-PHB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHB versus RIPOR2 in LSCC, with a Pearson correlation of -0.26.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHB→partner) and Y-score (partner→PHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RIPOR2 →	-0.844	-0.272	<.001	.004	2	8
OV	EMG1 →	+0.677	+0.444	<.001	<.001	3	7
OV	PHB2 →	+0.667	+0.409	<.001	<.001	3	7
LSCC	IL33 →	-1.345	-0.346	<.001	<.001	3	6
BRCA	IFITM2 →	-0.780	-0.273	.001	.001	3	6
OV	CEP85L →	-0.626	-0.439	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,699 associations by consensus.

PHB vs RIPOR2 — LSCC

Explore this scatter interactively →