PHB

Across TCGA patient cohorts, PHB mutation is significantly associated with the RNA expression of many other genes, with 673 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHB-associated genes across cancer lineages are CWC25, ZNHIT3, and TAF9. Each is linked with PHB in more than 1 cancer types. Because this analysis shows association rather than direction, both PHB-to-partner and partner-to-PHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CWC25 grouped by PHB-low versus PHB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHB→partner) and Y-score (partner→PHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CWC25 →	+0.411	+2.716	.004	.003	3	1
UCEC	ZNHIT3 →	+0.544	+3.108	<.001	<.001	3	1
UCEC	TAF9 →	+0.606	+3.807	<.001	<.001	3	1
UCEC	INO80B-WBP1 →	+0.081	+2.407	.004	.006	3	1
UCEC	LINC02340 →	+0.383	+3.689	<.001	.001	3	1
UCEC	MIR4449 →	+0.429	+1.780	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 673 associations by consensus.

CWC25 by PHB expression — UCEC

Explore this box plot interactively →