PHB

Across TCGA patient cohorts, PHB mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHB-associated genes across cancer lineages are ER-alpha, Fibronectin, and Ku80. Each is linked with PHB in more than 1 cancer types. Because this analysis shows association rather than direction, both PHB-to-partner and partner-to-PHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha grouped by PHB-low versus PHB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHB→partner) and Y-score (partner→PHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha →	+0.830	+2.820	.036	.035	3	1
UCEC	Fibronectin →	-0.346	-3.160	.030	.019	3	1
UCEC	Ku80 →	+0.227	+2.817	.046	.036	3	1
UCEC	AMPK_pT172 →	+0.507	+3.598	.010	.001	3	1
UCEC	Tuberin_pT1462 →	+0.300	+3.009	.007	.019	3	1
UCEC	Caspase-8 →	-0.240	-2.459	.047	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ER-alpha by PHB expression — UCEC

Explore this box plot interactively →