PHB

Across TCGA cell cohorts, PHB RNA expression is significantly associated with the go_rna of many other GO terms, with 4,948 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PHB-associated GO terms across cancer lineages are Mitochondrial ribosome assembly, Ribosomal large subunit assembly, and Ribosome assembly. Each is linked with PHB in more than 15 cancer types. Because this analysis shows association rather than direction, both PHB-to-partner and partner-to-PHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial ribosome assembly grouped by PHB-low versus PHB-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHB→partner) and Y-score (partner→PHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Mitochondrial ribosome assembly →	+0.104	+1.003	.001	<.001	3	16
BONE	Ribosomal large subunit assembly →	+0.133	+0.949	.001	.001	3	16
BLOOD_Myeloma	Ribosome assembly →	+0.112	+1.327	<.001	<.001	3	16
BLOOD_Myeloma	rRNA 5'-end processing →	+0.130	+0.941	<.001	.007	3	15
URINARY_TRACT	rRNA metabolic process →	+0.112	+1.483	<.001	<.001	3	15
BONE	Ribosome biogenesis →	+0.133	+0.968	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,948 associations by consensus.

Mitochondrial ribosome assembly by PHB expression — BONE

Explore this box plot interactively →