PHAX

Across TCGA pan-cancer cohorts, PHAX mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PHAX data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PHAX mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PHAX expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

COAD, CCRCC, and GBM are the cancer types where PHAX mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.904	1.000	.036	12	view →
CCRCC	DFS	Median	IV	0.781	0.220	.017	9	view →
GBM	OS	Median	All	0.462	0.273	.011	8	view →
PDAC	OS	Tertile	III,IV	0.188	0.645	.017	7	view →
UCEC	OS	Median	II,III,IV	1.000	0.680	.034	4	view →
HNSC	OS	Median	All	1.000	0.961	.031	3	view →
LUAD	OS	Quartile	II,III,IV	0.846	0.466	.044	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PHAX–COAD (DFS)

Open the COAD breakdown →