PHAX

Across TCGA patient cohorts, PHAX mutation is significantly associated with the RNA expression of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHAX-associated genes across cancer lineages are RNA5SP412, RNA5SP419, and RNA5SP408. Each is linked with PHAX in more than 1 cancer types. Because this analysis shows association rather than direction, both PHAX-to-partner and partner-to-PHAX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by PHAX-low versus PHAX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHAX→partner) and Y-score (partner→PHAX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.620	+2.967	.008	.007	3	2
UCEC	RNA5SP419 →	+1.052	+3.077	<.001	.005	3	2
UCEC	RNA5SP408 →	+0.400	+3.450	.003	.005	3	2
UCEC	RNA5SP410 →	+1.186	+3.526	<.001	.001	3	2
UCEC	RNA5SP421 →	+1.044	+3.340	<.001	.001	3	2
UCEC	MIR6857 →	+0.372	+3.621	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

RNA5SP412 by PHAX expression — UCEC

Explore this box plot interactively →