PHAX

Across TCGA cell cohorts, PHAX mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHAX-associated genes across cancer lineages are DMRTC2, GUCA2A, and OR11H2. Each is linked with PHAX in more than 1 cancer types. Because this analysis shows association rather than direction, both PHAX-to-partner and partner-to-PHAX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DMRTC2 grouped by PHAX-low versus PHAX-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHAX→partner) and Y-score (partner→PHAX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DMRTC2 →	+0.009	+4.643	<.001	.005	3	1
BLOOD_Leukemia	GUCA2A →	+0.052	+5.969	<.001	.001	3	1
BLOOD_Leukemia	OR11H2 →	+0.060	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KRTAP7-1 →	+0.095	+5.539	<.001	.003	3	1
LARGE_INTESTINE	HSFY2 →	+0.023	+4.977	<.001	.007	3	1
OVARY	DAZ2 →	+0.106	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

DMRTC2 by PHAX expression — BLOOD_Lymphoma

Explore this box plot interactively →