PHACTR2-AS1

Across TCGA pan-cancer cohorts, PHACTR2-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PHACTR2-AS1 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher PHACTR2-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PHACTR2-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and LUAD show a favorable association.

LUSC, LUAD, and KIRP are the cancer types where PHACTR2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.732	0.588	<.001	91	view →
LUAD	DFS	Median	All	0.728	0.588	.009	45	view →
KIRP	DFS	Tertile	IV	0.033	0.459	<.001	45	view →
UCS	OS	Tertile	IV	0.132	0.682	.003	26	view →
KICH	DFS	Median	All	1.000	0.743	.007	23	view →
SKCM	OS	Quartile	All	0.462	0.308	.003	18	view →
THCA	OS	Median	IV	0.560	0.939	.002	12	view →
PAAD	OS	Median	III,IV	0.629	1.000	.022	9	view →
LIHC	OS	Tertile	II,III,IV	1.000	0.718	.027	9	view →
CHOL	DFS	Tertile	All	0.838	0.237	.022	6	view →
PRAD	DFS	Median	All	0.844	0.914	.010	6	view →
LGG	DFS	Median	All	0.536	0.333	.018	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PHACTR2-AS1–LUSC (DFS)

Open the LUSC breakdown →