PHACTR1

Across TCGA patient cohorts, PHACTR1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHACTR1-associated genes across cancer lineages are PCNA, MEK1, and FOXO3a_pS318_S321. Each is linked with PHACTR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHACTR1-to-partner and partner-to-PHACTR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PHACTR1-low versus PHACTR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHACTR1→partner) and Y-score (partner→PHACTR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.246	+1.584	<.001	.005	3	3
UCEC	MEK1 →	+0.370	+2.736	.001	<.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.114	-1.238	.003	.041	3	2
UCEC	ACVRL1 →	-0.106	-1.687	.013	.040	3	2
UCEC	Notch1 →	+0.123	+1.137	.005	.041	3	2
UCEC	p70-S6K_pT389 →	-0.156	-2.115	.009	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

PCNA by PHACTR1 expression — UCEC

Explore this box plot interactively →