PHACTR1

Across TCGA cell cohorts, PHACTR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,900 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PHACTR1-associated GO terms across cancer lineages are Random inactivation of X chromosome, Constitutive secretory pathway, and Response to glycine. Each is linked with PHACTR1 in more than 7 cancer types. Because this analysis shows association rather than direction, both PHACTR1-to-partner and partner-to-PHACTR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Random inactivation of X chromosome grouped by PHACTR1-low versus PHACTR1-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHACTR1→partner) and Y-score (partner→PHACTR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Random inactivation of X chromosome →	+0.079	+2.256	.006	<.001	3	8
LUNG_SCLC	Constitutive secretory pathway →	+0.117	+2.285	<.001	<.001	3	7
OVARY	Response to glycine →	+1.043	+1.168	<.001	<.001	3	7
BLOOD_Lymphoma	Negative regulation of autophagosome maturation →	+0.087	+2.138	.004	.001	3	7
LUNG_NSCLC_LUSC	Regulation of cardiac muscle cell contraction →	-0.178	-1.130	<.001	.002	3	7
SKIN	Organelle transport along microtubule →	+0.048	+2.765	.009	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,900 associations by consensus.

Random inactivation of X chromosome by PHACTR1 expression — BLOOD_Lymphoma

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