PHACTR1

Across TCGA cell cohorts, PHACTR1 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PHACTR1-associated genes across cancer lineages are MS4A10, ACTL7A, and FEV. Each is linked with PHACTR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHACTR1-to-partner and partner-to-PHACTR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A10 grouped by PHACTR1-low versus PHACTR1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHACTR1→partner) and Y-score (partner→PHACTR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MS4A10 →	+0.006	+3.459	<.001	.001	3	1
OVARY	ACTL7A →	+0.026	+3.104	<.001	.002	3	1
SKIN	FEV →	+0.068	+3.823	.008	.006	3	1
SKIN	C10orf53 →	+0.021	+3.345	<.001	.007	3	1
SKIN	GPR21 →	+0.023	+3.878	.004	.003	3	1
SKIN	GSG1L2 →	+0.011	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MS4A10 by PHACTR1 expression — OVARY

Explore this box plot interactively →