PGRMC2

Across TCGA pan-cancer cohorts, PGRMC2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PGRMC2 data layer compared with 17 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher PGRMC2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PGRMC2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

GBM, CCRCC, and HNSC are the cancer types where PGRMC2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.582	0.868	.009	18	view →
CCRCC	DFS	Quartile	All	1.000	0.810	.024	10	view →
HNSC	DFS	Tertile	III,IV	1.000	0.934	.038	5	view →
UCEC	DFS	Quartile	All	0.818	1.000	.044	2	view →
PDAC	OS	Median	II,III,IV	0.584	0.406	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PGRMC2–GBM (DFS)

Open the GBM breakdown →