PGRMC2

Across TCGA patient cohorts, PGRMC2 protein abundance is significantly associated with the RNA expression of many other genes, with 5,250 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PGRMC2-associated genes across cancer lineages are SOCS2, NCAPD3, and SPDL1. Each is linked with PGRMC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PGRMC2-to-partner and partner-to-PGRMC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PGRMC2 versus SOCS2 in GBM, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGRMC2→partner) and Y-score (partner→PGRMC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SOCS2 →	-1.105	-0.187	<.001	.002	3	4
OV	NCAPD3 →	-0.588	-0.259	.002	.004	3	3
COAD	SPDL1 →	-0.530	-0.146	.001	.009	3	3
GBM	NES →	-0.948	-0.248	<.001	<.001	3	3
UCEC	KANSL2 →	-0.566	-0.396	.004	.001	3	3
GBM	LRP8 →	-0.616	-0.198	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,250 associations by consensus.

PGRMC2 vs SOCS2 — GBM

Explore this scatter interactively →