PGRMC2

Across TCGA patient cohorts, PGRMC2 mutation is significantly associated with the RNA expression of many other genes, with 183 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGRMC2-associated genes across cancer lineages are HMGB3P3, SNRPGP17, and LINC01050. Each is linked with PGRMC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGRMC2-to-partner and partner-to-PGRMC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB3P3 grouped by PGRMC2-low versus PGRMC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGRMC2→partner) and Y-score (partner→PGRMC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMGB3P3 →	+0.247	+2.758	<.001	.003	3	2
UCEC	SNRPGP17 →	+0.398	+3.294	<.001	<.001	3	1
UCEC	LINC01050 →	+0.215	+2.287	.004	.009	3	1
UCEC	SNORD11B →	+0.576	+2.324	.002	.009	3	1
UCEC	LINC02084 →	+0.630	+3.202	<.001	.009	3	1
UCEC	RPS29P32 →	+0.652	+3.336	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 183 associations by consensus.

HMGB3P3 by PGRMC2 expression — UCEC

Explore this box plot interactively →