PGRMC2

Across TCGA cell cohorts, PGRMC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,683 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PGRMC2-associated GO terms across cancer lineages are Positive regulation of protein exit from endoplasmic reticulum, Regulation of response to endoplasmic reticulum stress, and Cellular response to topologically incorrect protein. Each is linked with PGRMC2 in more than 13 cancer types. Because this analysis shows association rather than direction, both PGRMC2-to-partner and partner-to-PGRMC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein exit from endoplasmic reticulum grouped by PGRMC2-low versus PGRMC2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PGRMC2→partner) and Y-score (partner→PGRMC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of protein exit from endoplasmic reticulum →	+0.186	+1.450	<.001	<.001	3	14
BLOOD_Myeloma	Regulation of response to endoplasmic reticulum stress →	+0.083	+0.850	.004	.002	3	13
BONE	Cellular response to topologically incorrect protein →	+0.094	+0.892	.001	.002	3	13
BONE	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.079	+1.133	.002	.001	3	13
BONE	COPII-coated vesicle cargo loading →	+0.146	+1.159	<.001	<.001	3	13
BONE	Regulation of ER to Golgi vesicle-mediated transport →	+0.100	+1.011	.005	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,683 associations by consensus.

Positive regulation of protein exit from endoplasmic reticulum by PGRMC2 expression — BONE

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