PGRMC1

Across TCGA pan-cancer cohorts, PGRMC1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PGRMC1 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PGRMC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PGRMC1 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

HNSC, PDAC, and GBM are the cancer types where PGRMC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.291	1.000	.001	45	view →
PDAC	OS	Median	IV	0.381	0.951	.006	12	view →
GBM	DFS	Median	All	0.845	0.644	.002	10	view →
OV	DFS	Median	All	0.664	0.900	.013	8	view →
LUAD	OS	Median	II,III,IV	1.000	0.818	.014	4	view →
CCRCC	DFS	Median	All	1.000	0.871	.004	3	view →
UCEC	DFS	Quartile	All	0.860	1.000	.034	2	view →
LSCC	DFS	Median	II,III,IV	0.451	0.877	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PGRMC1–HNSC (DFS)

Open the HNSC breakdown →