PGRMC1

Across TCGA patient cohorts, PGRMC1 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,883 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PGRMC1-associated proteins across cancer lineages are PGRMC1_S181, MAP3K8_S141, and PGRMC1_S57. Each is linked with PGRMC1 in more than 7 cancer types. Because this analysis shows association rather than direction, both PGRMC1-to-partner and partner-to-PGRMC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PGRMC1 versus PGRMC1_S181 in HNSC, with a Pearson correlation of 0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PGRMC1→partner) and Y-score (partner→PGRMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PGRMC1_S181 →	+0.901	+1.009	<.001	<.001	3	8
HNSC	MAP3K8_S141 →	-0.407	-1.307	.001	.004	3	6
HNSC	PGRMC1_S57 →	+0.712	+1.369	<.001	<.001	3	5
LUAD	HUWE1 →	+0.259	+0.587	<.001	<.001	3	5
HNSC	OCRL →	+0.416	+0.738	<.001	<.001	3	5
HNSC	ZNF280C →	+0.420	+0.848	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,883 associations by consensus.

PGRMC1 vs PGRMC1_S181 — HNSC

Explore this scatter interactively →