PGRMC1

Across TCGA patient cohorts, PGRMC1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGRMC1-associated genes across cancer lineages are EGFR_pY1068, eIF4G, and A-Raf_pS299. Each is linked with PGRMC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGRMC1-to-partner and partner-to-PGRMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PGRMC1-low versus PGRMC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGRMC1→partner) and Y-score (partner→PGRMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.351	-2.807	.001	.003	3	1
UCEC	eIF4G →	+0.361	+2.999	.007	.035	3	1
UCEC	A-Raf_pS299 →	-0.170	-2.115	.001	.019	3	1
UCEC	FoxM1 →	+0.283	+2.807	.012	.003	3	1
UCEC	ACC1 →	+0.464	+3.013	.003	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.225	-2.102	.002	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

EGFR_pY1068 by PGRMC1 expression — UCEC

Explore this box plot interactively →