PGRMC1

Across TCGA cell cohorts, PGRMC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,553 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PGRMC1-associated GO terms across cancer lineages are scaRNA localization to Cajal body, Regulation of amyloid fibril formation, and DNA repair-dependent chromatin remodeling. Each is linked with PGRMC1 in more than 9 cancer types. Because this analysis shows association rather than direction, both PGRMC1-to-partner and partner-to-PGRMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, scaRNA localization to Cajal body grouped by PGRMC1-low versus PGRMC1-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PGRMC1→partner) and Y-score (partner→PGRMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	scaRNA localization to Cajal body →	+0.072	+0.932	.001	<.001	3	10
BLOOD_Leukemia	Regulation of amyloid fibril formation →	+0.087	+0.494	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	DNA repair-dependent chromatin remodeling →	+0.090	+0.860	.001	.001	3	9
BLOOD_Lymphoma	Tail-anchored membrane protein insertion into ER membrane →	+0.079	+0.962	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Cell cycle checkpoint signaling →	+0.101	+1.133	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle process →	+0.089	+1.153	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,553 associations by consensus.

scaRNA localization to Cajal body by PGRMC1 expression — BLOOD_Lymphoma

Explore this box plot interactively →