Across TCGA patient cohorts, PGPEP1L mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGPEP1L-associated genes across cancer lineages are Notch1, p38-MAPK_pT180_Y182, and Annexin-1. Each is linked with PGPEP1L in more than 1 cancer types. Because this analysis shows association rather than direction, both PGPEP1L-to-partner and partner-to-PGPEP1L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGPEP1L→partner) and Y-score (partner→PGPEP1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.252	+2.183	<.001	.033	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.463	-3.000	.033	.036	3	1
UCEC	Annexin-1 →	+0.818	+3.019	.001	.019	3	1
UCEC	ATM →	-0.539	-2.459	.013	.020	3	1
UCEC	Caspase-8 →	-0.276	-3.143	.023	.018	3	1
UCEC	Rab25 →	-0.419	-3.000	.008	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

PGPEP1L survival (RNA) · tumor vs normal (RNA) · all PGPEP1L data types