PGPEP1

Across TCGA pan-cancer cohorts, PGPEP1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PGPEP1 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PGPEP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PGPEP1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

COAD, PDAC, and LSCC are the cancer types where PGPEP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.924	1.000	.015	30	view →
PDAC	DFS	Median	All	0.549	0.342	.014	13	view →
LSCC	OS	Quartile	II,III,IV	0.607	0.901	.013	11	view →
CCRCC	OS	Quartile	All	1.000	0.851	.013	10	view →
UCEC	DFS	Quartile	III,IV	0.451	1.000	.040	4	view →
GBM	OS	Quartile	All	0.533	0.916	.025	3	view →
HNSC	OS	Median	III,IV	0.513	1.000	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PGPEP1–COAD (DFS)

Open the COAD breakdown →