PGPEP1

Across TCGA cell cohorts, PGPEP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,239 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PGPEP1-associated GO terms across cancer lineages are GDF15-GFRAL signaling pathway, Fatty acid catabolic process, and Regulation of growth hormone receptor signaling pathway. Each is linked with PGPEP1 in more than 13 cancer types. Because this analysis shows association rather than direction, both PGPEP1-to-partner and partner-to-PGPEP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GDF15-GFRAL signaling pathway grouped by PGPEP1-low versus PGPEP1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PGPEP1→partner) and Y-score (partner→PGPEP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GDF15-GFRAL signaling pathway →	+1.432	+1.871	.009	<.001	3	14
LARGE_INTESTINE	Fatty acid catabolic process →	+0.066	+0.775	<.001	.007	3	12
OVARY	Regulation of growth hormone receptor signaling pathway →	+0.133	+1.027	<.001	<.001	3	11
SOFT_TISSUE	Reticulophagy →	+0.085	+1.075	<.001	<.001	3	11
URINARY_TRACT	Reduction of food intake in response to dietary excess →	+1.492	+1.065	.001	.001	2	12
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.095	-0.873	.002	.004	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,239 associations by consensus.

GDF15-GFRAL signaling pathway by PGPEP1 expression — LIVER

Explore this box plot interactively →